Phosphopeptide stabilised amorphous calcium phosphate complexes produced under acidic conditions

摘要

A phosphopeptide stabilised amorphous calcium phosphate (ACP) or amorphous calcium fluoride phosphate (ACFP) complex. The complex is formed a pH of 5.0 up to but below 7.0, and the ACP or ACP is predominantly in a basic form. The complex has both bound and unbound calcium, wherein the bound calcium in the complex is less than the bound calcium in a phosphopeptide stabilized ACP or ACFP complexes formed at a pH of 7.0. Preferably the phosphopeptide includes the sequence Ser(P)- Ser(P)- Ser(P)-Glu-Glu wherein Ser(p) is phosphoserine and Glu is glutamic acid.