2-pyridine-3-methylpyridine-thiophosphor-substituted as BACE-1 inhibitor and compounds containing BACE-1

摘要

The invention relates to a formula (III) pyrethroid derivative,R2 is h, F, Cl, Br, CN; R3 and R4 are h, F, Cl, CN; R6 is C1-C6, Alcoy C1-C6, C1-C6, halogen-hc, C1-C6, C17 is f or Cl; R8 is C1-C6, C1-C6, C1-C6, C3-C10 and other tar; R9 is h or C1-C6 tar. Favorite compounds: (a)(b)There are others It also relates to a preparation method and a drug synthesis. These compounds inhibit the separation of enzyme B (BACE-1) and the production of β - amide, which is an effective treatment for Alzheimer's disease, Down's syndrome, Parkinson's disease and other diseases.