Method for producing a composition comprising Epothilone (1S, 3S, 7S, 10R, 11S, 12S, 7, 11hidroxi 16R) - 3 - (2 - methyl - 5 - 5 - 10 - (IL) - prop - 2 - 1 - il) - 8.8 - - Tetramethyl - 4,17dioxabiciclo 14.1.0 12,16 Can heptade - 5.9 - dione

摘要

Refers to a method for producing a composition comprising an Epothilone, where this process consists in: a) Dissolving (1S, 3S, 7S, 10R, 11S, 12S, 16R) - 7:11 - dihydroxy - 3 - (2 - methyl - 5 - 5 - 10 - (IL) - prop - 2 - - 1 - il) - 4:17 8,8,12,16 - Tetramethyl - - [dioxabiciclo 14.1.0] heptadecan - 5.9 - dione in an organic Solvent such as ethanol, evaporating The Organic Solvent (b), (c) Dissolving hydroxypropyl - beta - Cyclodextrin in aqueous solution, (d) to adjust the PH of the resulting mixture b) between 5 and 9,(e) the resulting Dust b) dissolve in Solvents of reultantes (c) or (d), and then performing a sterile Filtration to obtain a Solution which removes the Solvent and obtain a Solid product