A new synthesis method of 7,8-dimethoxi-1,3-dihydro-2h-3-benzazepin-2-oa and its application in the synthesis of ivabradina and its salts

摘要

About the procedure of 7,8-dimethoxi-1,3-dihydro-2h-3-benzazepin-2-ona de formula (I),WHERE SUCH PROCEDURE CONSISTS IN TRANSFORMING THE ACID (3,4-DIMETOXIFENIL) ACETIC WITH THIONYL CHLORIDE, IN THE PRESENCE OF A DICLOROMETHANE SOLVENT AND A TEMPERATURE BETWEEN 20ºC TO 40ºC, IN A FORMULA COMPOUND (VI)The compound (VI) is then concentrated with an h2n-ch2-chr1rr2 compound to form a formula compound (V),An acidizing medium made from concentrated sulfuric acid that produces a formula compound (I) after insulation. X is halogens or an ocor3 group; R3 is C1-C6 tar, phenyl, benzene, etc.; R1 and R2 are alcox C1-C6, or combined with carbon atoms to form a 1.3-dioxan, 1.3-dioxolan or 1.3-dioxepano cycle. This compound (I) is the intermediate for the formation of ivabradina or its salts