Aqueous intravenous infusion solution or pharmaceutical solution comprising levosimendan

摘要

An aqueous intravenous infusion solution comprising levosimendan or a salt thereof as an active ingredient, the pH-value of the solution being lower than 5, preferably 4.5 or lower, and optionally a solubility enhancing agent. A pharmaceutical solution comprising (a) levosimendan or a pharmaceutically acceptable salt thereof as an active ingredient; (b) pharmaceutically acceptable organic solvent comprising ethanol; (c) a stability enhancing amount of pharmaceutically acceptable organic acid having pKa in the range of from 2 to 4; and optionally (d) a water-solubility enhancing agent.