New Compounds and their effects on the Feeding of Behaviorism

摘要

The Invention provides a Peptide Product comprising the Amino Acid Sequence is given below, together with the use of Peptide Product and Methods associated with them. The Peptide product is particularly useful as an appetite suppressant and for the treatment of Obesity.Xaa1 xaa2 xaa3 gly4 THR5 Phe6 thr7 ser8 asp9 tyr10 ser11 lys12 tyr13 leu14 xaa15 xaa16 xaa17 xaa18 xaa19 xaa20 xaa21 xaa22 xaa23 xaa24 trp25 leu26 xaa27 xaa28 xaa29 xaa30 xaa31 xaa32 lys33 asn34 asn35 ile36 ala37; where: xaa1 is his1 or D - his1, xaa2 is or Ala2 SER2,Xaa3 is gln3 or asp3; xaa15 xaa16 xaa17 xaa18 xaa19 xaa20 xaa21 xaa22 xaa23 xaa24 is: glu15 glu16 glu17 leu18 val19 lys20 tyr21 phe22 leu23 glu24, glu15 glu16 glu17 leu18 val19 lys20 tyr21 phe22 leu23 gln24, glu15 glu16 glu17 leu18 val19 lys20 tyr21 phe22 ile23 glu24, glu15 glu16 glu17 leu18 val19 L Ys20 tyr21 phe22 ile23 gln24, glu15 glu16 glu17 ile18 val19 lys20 tyr21 phe22 leu23 glu24,Glu15 glu16 glu17 ile18 val19 lys20 tyr21 phe22 leu23 gln24, glu15 glu16 glu17 ile18 val19 lys20 tyr21 phe22 ile23 glu24, glu15 glu16 glu17 ile18 val19 lys20 tyr21 phe22 ile23 gln24, glu15 gln16 glu17 leu18 val19 lys20 tyr21 phe22 leu23 glu24, glu15 gln16 glu17 leu18 val19 lys20 tyr21 phe22 leu23 g Ln24, glu15 gln16 glu17 leu18 val19 lys20 tyr21 phe22 ile23 glu24,Glu15 gln16 glu17 leu18 val19 lys20 tyr21 phe22 ile23 gln24, glu15 gln16 glu17 ile18 val19 lys20 tyr21 phe22 leu23 glu24, glu15 gln16 glu17 ile18 val19 lys20 tyr21 phe22 leu23 gln24, glu15 gln16 glu17 ile18 val19 lys20 tyr21 phe22 ile23 glu24, glu15 gln16 glu17 ile18 val19 lys20 tyr21 phe22 ile23 g Ln24,Or asp15 ser16 arg17 arg18 ala19 gln20 asp21 phe22 val23 gln24; xaa27 xaa28 xaa29 xaa30 xaa31 xaa32 is: met27 asn28 thr29 lys30 arg31 asn32, lys27 asn28 ala29 gly30 PRO31 ser32,Or lys27 asn28 gly29 gly30 PRO31 ser32 or a Peptide product as indicated above in which the residue is replaced with asn34 asp34; or a Peptide product as indicated above in which xaa3 is glu3; with the condition that if xaa15 xaa16 xaa17 xaa18 xaa19 xaa20 xaa21 xaa22 xaa23 xaa24 Ser16 arg17 is asp15 arg18 ala19 gln20 asp21 phe22 val23 gln24,Then xaa27 xaa28 xaa29 xaa30 xaa31 xaa32 is not met27 asn28 thr29 lys30 arg31 asn32