organostagno (iv) complexes with n - n-acetylcysteine to antitumour activity, process for their production and their use.

摘要

Organotin(IV) compounds with N-acetylcysteine having the general formula (1 ) o (2): wherein: R1, R2 and R3 are each independently selected from the group consisting of : H, an alkyl, alkoxyl, alkenyl or alkynyl group with up to 12 carbon atoms, an isocyclic or heterocyclic aromatic or aralkyl group with up to 12 carbon atoms, and they are preferably chosen from methyl, ethyl, butyl or phenyl, are synthetized by simple procedures from commercial products, and are active as anticancer agents. In particular, the Bu2Sn-N-acetylcysteinate derivative was found to have a potent and selective anticancer activity in vitro against several cancer cell lines.