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ANTIGENIC COMPLEX CONTAINING AN IMMUNOSTIMULATING PEPTIDE, CD4 AND CHEMOKIN RECEPTOR DOMAIN FOR THE TREATMENT OF HIV AND IMMUNE DISEASES
ANTIGENIC COMPLEX CONTAINING AN IMMUNOSTIMULATING PEPTIDE, CD4 AND CHEMOKIN RECEPTOR DOMAIN FOR THE TREATMENT OF HIV AND IMMUNE DISEASES
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机译:包含免疫肽,CD4和趋化因子受体域的抗抗原复合物,可用于治疗HIV和免疫疾病
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摘要
The invention provides peptides comprising a sequence homologous to a portion of the CDR-2 like domain of CD4, covalently linked to a helper T cell epitope, and optionally to other immunostimulatory sequences as well. The invention provides for the use of such peptides as immunogens to elicit the production in mammals of high titer polyclonal auto-antibodies, which are specific to CD4 surface complex. These auto-antibodies prevent binding of HIV viral particles to CD4+ cells. The peptides are useful in pharmaceutical compositions, to provide an immunotherapy for HIV infection and to protect against HIV infection.
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