ANTIMITOTIC RHIZOXINE DERIVATIVES FROM BURKHOLDERIA RHIZOXINA, PROCESS FOR THEIR PREPARATION AND THEIR USE

摘要

The invention concerns four novel secondary metabolites of the Burkholderia rhizoxina endosymbiont, a method for isolating said compounds from cultures of the bacteria and the use of said substances. The invention aims at providing novel rhizoxin derivatives with an antimitotic effect. Therefore, the following substances 1-4 are isolated, said substances exhibiting potential antifungal, cytotoxic and antiproliferative properties.