首页>
外国专利>
ORODISPERSIBLE PHARMACEUTICAL COMPOSITION FOR ORAL, OROMUCOSAL OR SUB-LINGUAL ADMINISTRATION OF AGOMELATIN
ORODISPERSIBLE PHARMACEUTICAL COMPOSITION FOR ORAL, OROMUCOSAL OR SUB-LINGUAL ADMINISTRATION OF AGOMELATIN
展开▼
机译:可用于口服,口服或舌下给药的阿戈美汀的可药用的药物组合物
展开▼
页面导航
摘要
著录项
相似文献
摘要
A coated solid orodispersible pharmaceutical composition comprises a central core or a central layer containing agomelatine and excipients allowing the orodispersible formulation to be obtained, and an orodispersible coating. Independent claims are also included for the following: (1) preparing the composition involving mixing constituents of the core and then compressing by direct compression, and then mixing the constituents of the coating layer, where the coating is carried out by compression of the resulting powder mixture around the cores; and (2) manufacturing a coating for the coated solid orodispersible composition involving disintegrating the composition in the mouth in less than 3 minutes (preferably less than 1 minute), where citric acid is mixed with granules consisting of lactose and starch dried by co-atomization. ACTIVITY : Antidepressant; Hypnotic; Cardiovascular-Gen.; Gastrointestinal-Gen.; Muscular-Gen.; CNS-Gen.; Immunomodulator; Eating-Disorders-Gen; Anabolic; Anorectic. No biological data is given. MECHANISM OF ACTION : 5-Hydroxytryptamine-2c receptor antagonist; Melatoninergic system receptor agonist.
展开▼