USE OF DIFENIL-UREAS REPLACED WITH OMEGA-CARBOXIARILO AS INHIBITORS OF THE QUINASA RAF.

摘要

A compound of Formula I: A-D-B (I) or a pharmaceutically acceptable salt thereof, in which D is -NH-C (O) -NH-, A is a substituted moiety of up to 40 carbon atoms of the formula: -L- (ML 1) q, where L is a 5 or 6-member cyclic structure linked directly to D, L1 comprises a substituted cyclic moiety having at least 5 members, M is a bridge forming group having at least one atom, q is an integer from 1 to 3; and each cyclic structure of L and L1 contains 0-4 members of the group consisting of nitrogen, oxygen and sulfur, and B is a substituted or unsubstituted aryl or heteroaryl moiety, up to tricyclic having up to 30 carbon atoms with at least one cyclic structure 6-member directly linked to D containing 0-4 members of the group consisting of nitrogen, oxygen and sulfur, where L1 is substituted with at least one substituent selected from the group consisting of -SO2Rx, -C (O) Rx and -C (NRy) Rz, Ry is hydrogen or a carbon-based moiety of up to 24 carbon atoms optionally containing heteroatoms selected from N, S and O and optionally halosubstituted, until per-halo, Rz is hydrogen or a carbon-based moiety of up to 30 carbon atoms optionally containing heteroatoms selected from N, S and O and optionally substituted with halogen, hydroxy and carbon-based substituents of up to 24 carbon atoms, containing option Highly heteroatoms selected from N, S and O and are optionally substituted with halogen.