USE OF EXAPEPTIDES TO PREPARE INHIBITING FORMULATIONS OF THE CONVERSING ENGINE OF ANGIOTENSIN I.

摘要

The invention consists in using synthetic hexapeptides as bioactive products. These are peptides with six amino acid residues as effective inhibitors of angiotensin converting enzyme (ACE). The peptides that are the subject of the patent may be obtained chemically or biotechnologically. Of special interest are those synthesized exclusively from the D-stereoisomers of natural amino acids since this method affords greater stability in addition to their in vitro and/or ex vivo angiotensin converting enzyme inhibitory activity measured as the reduction in the contraction of rabbit carotid arteries induced by exposure to angiotensin 1. These nutraceutical products, possibly in the form of bioactive peptides, are useful both in the food industry and in the pharmaceutical industry.