SONIC HEDGEHOG MITOGENOUS EFFECT (SHH) ON OLIGODENDROCIT PRECURSORS AND ITS USE IN DEMIELINIZING DISEASES.

摘要

Mytogenic effect of Sonic hedgehog (Shh) on oligodendrocyte precursors and their use in demyelinating diseases. The present invention relates to the mitogenic effect of the Sonic hedgehog (Shh) protein on oligodendrocyte precursor cells. Specifically, and due to said mitogenic effect, the present invention comprises the use of Shh for the expansion of oligodendrocyte precursor cells in vitro , as well as its application in the preparation of pharmaceutical compositions for the treatment of demyelinating diseases.