Process for the preparation of esters of diacerein with hyaluronic acid and pharmaceutical preparations containing them.

摘要

Process for the preparation of stable esters of diacerein with hyaluronic acid anti-inflammatory activity prolonged and suitable for intra-articular administration, wherein diacerein, suitably protected in the carboxylic group with a carbodiimidazolilo radical, is reacted with hyaluronic acid , suitably salified with a strong quaternary base, at a temperature below 40 ° C temperature for a period of 4 to 48 hours in an aprotic solvent and in the presence of nitrogen and the reaction mass is then dialyzed and lyophilized to give compound wanted.