ESTER OF ACID 3- (REPLACED AMINO) -1H-INDOL-2-CARBOXYLIC AND DERIVATIVES OF ESTER OF ACID 3- (REPLACED AMINO) -BENZO (B) THIOPHEN-2-CARBOXYLIC AS EXHIBITORS OF EXPRESSION OF THE INTERLEUCINE-4 GEN.

摘要

Use of a compound selected from the group consisting of: 3- (4-pyridinylamino) -1H-indole-2-carboxylic acid ethyl ester, 6-trifluoromethyl-3- (4-pyridinylamino) -1H-indole acid ethyl ester -2-carboxylic acid, 6-chloro-3- (4-pyridinylamino) -1H-indole-2-carboxylic acid ethyl ester, 5-chloro-3- (4-pyridinylamino) -1H-indole-2 acid ethyl ester -carboxylic, 6-fluoro-3- (4-pyridinylamino) -1H-indole-2-carboxylic acid ethyl ester, 5-fluoro-3- (4-pyridinylamino) -1H-indole-2-carboxylic acid ethyl ester , 4-Fluoro-3- (4-pyridinylamino) -1H-indole-2-carboxylic acid tert-butyl ester, 6-phenyl-3- (4-pyridinylamino) -1H-indole-2-carboxylic acid ethyl ester , 3- (4-Pyridinylamino) -1H-indole-2-carboxylic acid tert-butyl ester, 5,6-dimethoxy-3- (4-pyridinylamino) -1H-indole-2-carboxylic acid ethyl ester, ester 3-Methoxy-3- (4-pyridinylamino) -1H-indole-2-carboxylic acid tert-butyl, 3- (2-pyridinyl acid ethyl ester) amino) -1H-indole-2-carboxylic acid, ethyl ester of 3- (pyrimidin-2-ylamino) -1H-indole-2-carboxylic acid, ethyl ester of 5-fluoro-1-methyl-3- (4- pyridinylamino) -1H-indole-2-carboxylic acid, 4-fluoro-1-methyl-3- (4-pyridinylamino) -1H-indole-2-carboxylic acid tert-butyl ester, 5-chloro-1 acid ethyl ester -methyl-3- (4-pyridinylamino) -1H-indole-2-carboxylic acid, ethyl ester of 6-chloro-1-methyl-3- (4-pyridinylamino) -1H-indole-2-carboxylic acid ethyl ester of 6-Chloro-1-diethylcarbamoylmethyl-3- (pyridin-4-ylamino) -1H-indole-2-carboxylic acid, pentafluorophenyl ester of 3- (4-pyridinylamino) -1H-indole-2-carboxylic acid, ester 2- 3- (4-Pyridinylamino) -1H-indole-2-carboxylic acid diethylamino-ethyl, 3- (4-pyridinylamino) -1H-indole-2-carboxylic acid 2-dimethylamino-ethyl ester, 2-piperidine- 3- (4-Pyridinylamino) -1H-indole-2-carboxylic acid 1-yl-ethyl, 3- (pyridin-4-ylamino) -1H-indole-2 acid (S) -1-methoxycarbonyl-ethyl ester -car Boxyl, 3- (pyridin-4-ylamino) -1H-indole-2-carboxylic acid ethoxycarbonylmethyl ester, 3- (4-pyridinylamino) -1H-indole-2-carboxylic acid 2-methoxyethyl ester, 3-ethoxypropyl ester of 3- (4-pyridinylamino) -1H-indole-2-carboxylic acid, 3- (pyridin-4-ylamino) -1H-indole-2-carboxylic acid indan-5-yl ester, diethylcarbamoylmethyl acid 3- 3- (Pyridin-4-ylamino) -1H-indole-2-carboxylic acid (2-morpholin-4-yl-2-oxo-ethyl ester) (pyridin-4-ylamino) -1H-indole-2-carboxylic acid 3- (Pyridin-4-ylamino) -1H-indole-2-carboxylic acid 2-oxo-2-pyrrolidin-1-yl-ethyl ester, 2-azetidin-1-yl-2-oxo-ethyl acid ester 3- (Pyridin-4-ylamino) -1H-indole-2-carboxylic acid ester (benzyl-ethyl-carbamoyl) -methyl ester 3- (pyridin-4-ylamino) -1H-indole-2-carboxylic acid, diethylcarbamoyloxy ester -3- (Pyridin-4-ylamino) -1H-indole-2-carboxylic acid methyl, 3- (pyridin-4-ylamino) -1H-indole-2-carboxylic acid benzylcarbamoylmethyl ester, ester 3- (Pyridin-4-ylamino) -1H-indole-2-carboxylic acid piperidine-1-carbonyloxymethyl, 3- (pyridin-4-ylamino) -1H-indole-2-carboxylic acid morpholine-4-carbonyloxymethyl ester , 3- (Pyridin-4-ylamino) -1H-indole-2-carboxylic acid, 2-ethoxycarbonylamino-2-oxyethyl ester, 3- (pyridine-4-ylamino) -1H-indole acid iso-propoxycarbonyloxy-methyl ester -2-carboxylic acid, 3- (pyridin-4-ylamino) -1H-indole-2-carboxylic acid 1,1,2-trimethylpropoxycarbonyloxymethyl ester, 3- (pyridine-) cyclohexyloxycarbonyloxymethyl ester 4-ylamino) -1H-indole-2-carboxylic acid, adamantan-1-yloxycarbonyloxymethyl ester of 3- (pyridin-4-ylamino) -1H-indole-2-carboxylic acid, 3- (pyridin-4- acid acetoxymethyl ester ylamino) -1H-indole-2-carboxylic acid, 2,2-dimethyl-propionyloxymethyl ester of 3- (pyridin-4-ylamino) -1H-indole-2-carboxylic acid, pentanoyloxymethyl ester of 3- (pyridin-4- ylamino) -1H-indole-2-carboxylic acid, 2-oxo-piperidin-1-ylmethyl ester 3- (Pyridin-4-ylamino) -1H-indole-2-carboxylic acid ester (benzoyl-ethoxycarbonylmethyl-amino) -methyl ester 3- (pyridin-4-ylamino) -1H-indole-2-carboxylic acid, ester 3- (Pyridin-4-ylamino) -1H-indole-2-carboxylic acid, 2-oxo-pyrrolidin-1-ylmethyl acid, 5-methyl-2-oxo- (1,3) dioxo-4-ylmethyl acid ester 3- (Pyridin-4-ylamino) -1H-indole 3- (pyridine-4-sulfonyl) -amino) -methyl (3- (pyridin-4-ylamino) -1H-indole) -2-carboxylic, 3- (pyridin-4-ylamino) -1H-indole-2-carboxylic acid (benzenesulfonyl-methyl-amino) -methyl ester, ester (methyl- (toluene-4-sulfonyl) -amino) - 3- (pyridin-4-ylamino) -1H-indole-2-carboxylic acid methyl, 3- (pyridin-4-ylamino) -1H-indole-2-carboxylic acid tert-butoxycarbonyloxy-methyl ester, ethyl ester of 3- (4-Pyridinylamino) -benzo (b) thiophene-2-carboxylic acid, 3- (4-pyridinylamino) -6-trifluoromethyl-benzo (b) thiophene-2-carboxylic acid hydrochloride salt, ester á ethyl 6-fluoro-3- (4-pyridinylamino) -benzo (b) thiophene-2-carboxylic acid, 3 - ((4-pyridyl) amino-N-methyl) -benzo (b) thiophenyl-2-carboxylic acid ethyl ester, 3- (propyl-4-pyridinylamino) -benzo (b) thiophene-2-carboxylic acid ethyl ester, 3 - ((benzoyl) amino) -6-chloro-1H-indole-2 acid -carboxylic acid ethyl ester of 3 - ((benzoyl) methylamino) -4,6-dichloro-1H-indole-2-carboxylic acid ethyl ester of 3 - ((benzoyl) benzylamino) -4,6-dichloro-1H -indole-2-carboxylic acid, and 3 - ((phenylsulfonyl) amino) -4,6-dichloro-1H-indole-2-carboxylic acid ethyl ester for the preparation of a pharmaceutical composition useful in the treatment of allergy, asthma, rhinitis, dermatitis, B lymphocyte lymphomas, tumors, antibacterial infections, rhinovirus or respiratory syncytial virus (RSV).