QUINUCLIDINE DERIVATIVES THAT JOIN M3 MUSCARINIC RECEPTORS.

摘要

A compound of the formula I ** (See formula) ** in salt or in the form of zwitterion in which R1 and R3 are each independently a C3-C15 carbocyclic group or a 4- to 12-membered heterocyclic group minus a heteroatom ring selected from nitrogen, oxygen and sulfur, or -CR1R2R3 that together form a group of formula ** (See formula) ** where R is a bond, -O-, -S-, -CH2-, -CH = CH-, -CH2-CH2-, amino or N (CH3) -; R2 is hydrogen, halo, hydroxy, C1-C8-alkoxy or C1-C8-alkyl optionally substituted by hydroxy; R4 is C1-C8-alkyl substituted by -NR5-CO-R6 or -CO-NR9R10; R5 is hydrogen or C1-C8-alkyl; R6 is C1-C8-alkyl, C2-C8-alkenyl, C2-C10-alkynyl or C1-C8-alkoxy in each case optionally substituted by a heterocyclic group with 4 to 12 members with at least one heteroatom ring selected from nitrogen, oxygen and sulfur, or R6 is a heterocyclic group with 4 to 12 members with at least one heteroatom ring selected from nitrogen, oxygen and sulfur; R9 is hydrogen or C1-C8-alkyl; and R10 is hydrogen, C1-C8-alkyl optionally substituted by cyanide, amino, nitro, carboxy, C1-C8-alkoxy, or by a heterocyclic group having 4 to 12 members with at least one heteroatom ring selected from oxygen nitrogen and sulfur, or R10 is a heterocyclic group with 4 to 12 members with at least one heteroatom ring selected from nitrogen, oxygen and sulfur.