AMINO PHENYLACETIC ACIDS SUBSTITUTED, DERIVED FROM THE SAME, ITS PREPARATION AND ITS USE AS CYCLOOXIGENASA 2 (COX-2) INHIBITORS.

摘要

A compound of formula (I) ** see formula ** wherein R is located in position 5 and is C1-C4 alkyl, cycloalkyl (C3-C6), hydroxy, halo, methoxy, ethoxy, trifluoromethoxy, trifluoromethyl or cyano; and A is optionally substituted quinolinyl; optional substituents are selected from C1-C4 alkyl, methoxy, ethoxy, halo and trifluoromethyl; or a pharmaceutically acceptable salt thereof; or a pharmaceutically acceptable ester thereof selected from the group consisting of C1-C4 alkyl esters, C1-C4 carboxy alkyl esters and nitrooxy- or nitrosooxy C1-C4 alkyl esters.