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COMPOUNDS TO TREAT SCHISOPHRENIA AND / OR ANOMALIES IN THE GLUCOSE REGULATION.
COMPOUNDS TO TREAT SCHISOPHRENIA AND / OR ANOMALIES IN THE GLUCOSE REGULATION.
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机译:葡萄糖调节中治疗精神分裂症和/或异常的化合物。
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摘要
A compound of formula I ** (See formula) ** where m is 0, 1 or 2; n is 0, 1 or 2; p is 0 or 1; each R is independently hydrogen, halogen, trifluoromethyl, C1-C6 alkyl, C1-C6 alkoxy, benzyloxy, hydroxy, nitro or amino; each R1 is independently hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C1-C6 alkanoyl, halogen, cyano, -C (O) C1-C6 alkyl, -C1-C6 alkylene, CN-C1-C6 alkylene ) NR''R '' '' where R '' and R '' '' are each independently hydrogen or C1-C6 alkyl, (C1-C6) alkylene (OC) C1-C6 alkyl, or -CH ( OH) R4 where R4 is hydrogen or C1-C6 alkyl; R2 is hydrogen, C1-C6 alkyl optionally substituted by halogen, hydroxy or benzyloxy, C2-C6 alkenyl, C2-C6 alkynyl, -CO2 C1-C6 alkyl, or -R5-NR '' R '' '' where R5 is C1 alkylene -C6, C2-C6 alkenylene or C2-C6 alkynylene and R '' and R '' '' are each independently hydrogen, C1-C6 alkyl or alternatively the group -NR''R '' '' together is 1- pyrrolidinyl; and R3 is hydrogen, nitro, amino, halogen, C1-C6 alkoxy, hydroxy or C1-C6 alkyl. or one of its pharmaceutically acceptable salts, for use in the treatment of schizophrenia in a human being.
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