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Procedure for the preparation of valsartan and simvastatin combinations (Machine-translation by Google Translate, not legally binding)
Procedure for the preparation of valsartan and simvastatin combinations (Machine-translation by Google Translate, not legally binding)
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机译:缬沙坦和辛伐他汀组合的制备程序(由Google翻译进行机器翻译,不具有法律约束力)
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摘要
Procedure for the preparation of combinations of valsartan and simvastatin. The present invention relates to a new process for the preparation of amorphous combinations of valsartan and simvastatin in the form of micron particles, comprising introducing a solution with the active principles into a particle-forming container, and a compressed fluid under supercritical conditions, wherein the container in which the particles are formed is at a pressure comprised between atmospheric pressure and 10 bar. It also refers to the amorphous combinations obtainable according to the process of the invention, to their use for the preparation of solid dosage forms for oral administration, and also to said solid dosage forms. Said amorphous combinations present an improved wettability and remain in an amorphous state after long periods of storage. (Machine-translation by Google Translate, not legally binding)
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