NUCLEIC ACIDS OF ROCHALIMAEA HENSELAE AND ROCHALIMAEA QUINTANA AND METHODS AND COMPOSITIONS FOR DIAGNOSING ROCHALIMAEA HENSELAE AND ROCHALIMAEA QUINTANA INFECTION

摘要

A method of diagnosing cat scratch disease and a method of diagnosing bacillary angiomatosis in a subject by detecting the presenceof Rochalimaea henselae or an antigenic fragment thereof in the subject provided. Also provided is a vaccine comprising an immunogenicamount of a nonpathogenic Rochalimaea henselae or an immunogenically specific determinant thereof and a pharmaceutically acceptablecarrier. A method of diagnosing Rochalimaea quintana infection in a subject by detecting the presence of a nucleic acid specific toRochalimaea quintana in a sample from the subject is provided. A purified, 60-kDa heat shock protein of Rochalimaea is provided. Alsoprovided is a 17-kDa antigenic polypeptide of Rochalimaea.