REPLICATION-COMPETENT HERPES SIMPLEX VIRUS MEDIATES DESTRUCTION OF NEOPLASTIC CELLS

摘要

A method for killing malignant brain tumor cells in vivo entails providingreplication competent herpes simplex virus vectors to tumorcells. A replication competent herpes simplex virus vector, with defectiveexpression of the .gamma.34,5 gene and the ribonucleotide reductasegene, specifically destroys tumor cells, is hypersensitive to anti-viralagents, and yet is not neurovirulent.