PACKAGING CELL LINES FOR USE IN FACILITATING THE DEVELOPMENT OF HIGH-CAPACITY ADENOVIRAL VECTORS

摘要

The present invention relates to gene therapy, especially to adenovirus-basedgene therapy, and related cell lines and compositions.In particular, novel packaging cell lines are disclosed, for use infacilitating the development of high-capacity vectors. The invention alsodiscloses a variety of high-capacity adenovirus vectors and relatedcompositions and kits including the disclosed cell lines and vectors.Finally, the invention discloses methods of preparing and using the disclosedvectors, cell lines and kits.