THERAPY FOR HUMAN CANCERS USING CISPLATIN AND OTHER DRUGS OR GENES ENCAPSULATED INTO LIPOSOMES

摘要

A method for encapsulating cisplatin and other positively-charged drugs intoliposomes having a different lipidcomposition between their inner and outer membrane bilayers is disclosed. Theliposomes are able to reach primary tumors and theirmetastases after intravenous injection to animals and humans. The encapsulatedcisplatin has a high therapeutic efficacy ineradicating a variety of solid human tumors including but not limited tobreast carcinoma and prostate carcinoma. Combination of theencapsulated cisplatin with encapsulated doxorubicin or with otherantineoplastic drugs are claimed to be of therapeutic value. Alsoof therapeutic value in cancer eradication are claimed to be combinations ofencapsulated cisplatin with a number of anticancer genesincluding but not limited to p53, IL-2, IL-12, angiostatin, and oncostatinencapsulated into liposomes as well as combinations ofencapsulated cisplatin with HSV-tk plus encapsulated ganciclovir.