DELIVERY OF SEDATIVE-HYPNOTICS THROUGH AN INHALATION ROUTE

摘要

The present invention relates to the delivery of sedative-hypnotics through aninhalation route. Specifically, it relates to aerosols containing sedative-hypnotics that are used in inhalation therapy. In a composition aspect of thepresent invention, the aerosol comprises particles comprising at least 5percent by weight of a sedative-hypnotic. In a method aspect of the presentinvention, a sedative-hypnotic is delivered to a mammal through an inhalationroute. The method comprises: a) heating a composition, wherein the compositioncomprises at least 5 percent by weight of a sedative-hypnotic, to form avapor; and, b) allowing the vapor to cool, thereby forming a condensationaerosol comprising particles, which is inhaled by the mammal. In a kit aspectof the present invention, a kit for delivering a sedative-hypnotic through aninhalation route to a mammal is provided which comprises: a) a compositioncomprising at least 5 percent by weight of a sedative-hypnotic; and, b) adevice that forms a sedative-hypnotic containing aerosol from the composition,for inhalation by the mammal.