ANTIBODIES FOR PREVENTING AND TREATING ATTACHING AND EFFACING ESCHERICHIA COLI (AEEC) ASSOCIATED DISEASES

摘要

The present invention relates to antibodies immunologically specific for anattaching and effacing Escherichia coli (AEEC) virulence-associated protein,products, compositions and methods and to their use thereof in the preventionof an AEEC infection in a mammal. The antibody of the invention isimmunologically specific for an AEEC virulence-associated protein and iscapable of preventing an in vivo AEEC intestinal infection when administeredto a mammal. The antibody of the invention is preferably useful for preventingthe development of A/E intestinal lesions associated with the AEEC. This isachieved by preferably using lgY antibodies immunologically specific for oneor more AEEC virulence-associated proteins, such as Eae, Tir, EspA and Paa.