Characterization of the attaching and effacing mechanism of Escherichia coli in the pig intestine using in vivo, organ culture, and tissue culture infection models

摘要

Enteropathogenic E. coli (EPEC) cause diarrhea in infants1, rabbits2, calves, pigs3, lambs, and dogs4. Shiga toxin-producing E. coli (STEC), especially those of serotype 0157:H7, are important emerging pathogens causing food-borne infections leading to bloody diarrhea and hemolytic uremic syndrome in humans1. Ruminants are an important reservoir of STEC5. These STEC are carried at high frequency by cattle but have not been implicated in natural disease, although they may be used to experimentally reproduce disease in calves6.