TRICYCLIC COMPOUNDS PROTEIN KINASE INHIBITORS FOR ENHANCING THE EFFICACY OF ANTI-NEOPLASTIC AGENTS AND RADIATION THERAPY

摘要

Protein kinase, such as CHK-1, inhibiting tricyclic compounds of the followingformula (wherein R2, R3 and R4 are as defined in the specification)pharmaceutical compositions containing effective amounts of said compounds ortheir salts are useful as a single agent or in combination with an anti-neoplastic agent or therapeutic radiation having an anti-neoplastic effect fortreating diseases or conditions, such as cancers.