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SCREENING METHOD FOR IDENTIFYING PATIENTS AT RISK OF ADVERSE HEPATOLOGIC EVENTS
SCREENING METHOD FOR IDENTIFYING PATIENTS AT RISK OF ADVERSE HEPATOLOGIC EVENTS
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机译:不良肝病风险识别患者的筛查方法
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摘要
This present invention provides methods and kits for identifying patients atrisk of suffering from a drug inducedliver injury, particularly for an antioxidant drug, or for identifyingpatients who are suffering from early stages of a liver disorderby assessing the levels of apolipoprotein in a sample of the patient andcomparing that to a reference value. The reference value ispredetermined by identifying a population sample and determining an upperlimit of normal value. This value is then used as a referencepoint for comparison of apolipoprotein levels from patient samples. In oneembodiment, apolipoprotein levels are combinedwith ATL and/or total bilirubin levels for predicting liver damage,hepatotoxicity or hepatic events after drug administration.
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