IMPROVED METHODS FOR ISOLATING ENVELOPED VIRUS-BASED VLPS FREE OF INFECTIOUS AGENTS

摘要

Enveloped virus-based virus-like particles(VLPs) that are free of infectious agents and substantiallyas immunogenic as corresponding VLPs prior to inactivationof infectious agents are described. Improved methodsof inactivation infectious agents in preparations of envelopedvirus-based VLPs are also described wherein themethods do not adversely affect the immunogenicity of theVLPs.