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Listeria attenuated for entry into non-phagocytic cells, vaccines comprising the listeria, and methods of use thereof
Listeria attenuated for entry into non-phagocytic cells, vaccines comprising the listeria, and methods of use thereof
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机译:用于进入非吞噬细胞的减毒李斯特菌,包含该李斯特菌的疫苗及其使用方法
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摘要
The present invention provides Listeria that are attenuated for entry into non-phagocytic cells as well as a variety of methods of inducing immune responses involving administering compositions comprising the attenuated Listeria. Some of the attenuated Listeria are mutant Listeria that comprise at least one mutation in a gene encoding an invasin, such as an internalin. Some of the attenuated Listeria are further attenuated for cell-to-cell spread. Pharmaceutical compositions and vaccines useful in the methods of the invention are further provided. Methods of making and improving vaccines are also provided.
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