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Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
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机译:具有多个能够共价键合到生物分子上的官能团的表面固定的聚电解质
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摘要
Disclosed are proteins which are covalently bound to a solid support at a first temperature where they have a first configuration, and then biomolecules are attached to the bound proteins at a higher temperature at which the proteins have more exposed functional groups, each such group being capable of covalently bonding to a biomolecule. The biomolecule can be, for example, a nucleic acid, including an amine functionalized oligonucleotide. The proteins can include, BSA (Bovine Serum Albumin) which can be bound using a reaction with the surface of a tosyl-activated microparticle.
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