Stable and taste masked pharmaceutical dosage form using porous apatite grains

摘要

A composite material comprising of carbonated hydroxyapatite and biopolymer was synthesized in the form of microsphere for biomedical applications via a novel colloidal technique. Novel colloidal suspensions were prepared by mixing phosphate salts, calcium salts and carbonate precursors with size ranging from nanometer to submicrometer, together with sufficient amount of biocompatible polymers, following by spherorization to form microspheres of various sizes. Nanostructure of the constituents allows final apatitic phase to be developed upon moisture exposure. Biologically or therapeutically active drugs can be encapsulated directly into the microspherical composites upon synthesis for biomedical applications such as orthopedics, dentistry, and drug delivery.