SIRNAS USEFUL FOR INHIBITING EXPRESSION OF TYROSINASE GENE, THE COMPOSITIONS COMPRISING THE SIRNAS AND THEIR USES

摘要

siRNAs useful for inhibiting expression of tyrosinase gene are provided, wherein the siRNA has the nucleotide sequence as shown in TYRO-1, TYRO-2, TYRO-3, TYRO-4, TYRO-5, TYRO-6, TYRO-7 or TYRO-8, or has the chemically modified nucleotide sequence derived from the nucleotide sequence as shown in TYRO-1, TYRO-2, TYRO-3, TYRO-4, TYRO-5, TYRO-6, TYRO-7 or TYRO-8. Cosmetic compositions and the uses of siRNAs in the preparation of a cosmetic composition for inhibiting melanin production and deposit or eliminating melanin are provided. The siRNAs have high activity for inhibiting the expression of tyrosinase gene, and can effectively inhibit melanin production and deposit.