首页> 外国专利> USE OF NF-KAPPAB INHIBITOR SN50 AND OPTIONALLY ANGIOTENSIN III AS THERAPEUTIC AGENTS IN THE TREATMENT OF EG HBV INFECTION

USE OF NF-KAPPAB INHIBITOR SN50 AND OPTIONALLY ANGIOTENSIN III AS THERAPEUTIC AGENTS IN THE TREATMENT OF EG HBV INFECTION

机译:NF-KAPPAB抑制剂SN50和可选血管紧张素III在治疗EG HBV感染中的治疗作用

摘要

The present invention is directed to the use of the peptide compound AIa-AIa-VaI-AIa- Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu- Met-Pro-OH as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilisate or liquide buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu- Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH optionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.
机译:本发明涉及肽化合物Ala-Ala-VaI-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Arg的用途Lys-Arg-Gln-Lys-Leu-Met-Pro-OH作为预防和/或治疗癌症,自身免疫性疾病,纤维化疾病,炎性疾病,神经退行性疾病,传染病,肺病,心脏和血管的治疗剂疾病和代谢性疾病。此外,本发明涉及药物组合物,其优选为冻干物或液体缓冲溶液或人工母乳制剂或含有肽Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-的肽的母乳代用品。 Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH任选与至少一种药学上可接受的载体,冷冻保护剂,冻干保护剂,赋形剂和/或稀释剂。

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