STRUCTURE OF A PROTEIN PHOSPHATASE 2A HOLOENZYME: INSIGHTS INTO TAU DEPHOSPHORYLATION

摘要

Embodiments of the present invention relate to crystals and atomic coordinates for PP2A, as well as methods for using these atomic coordinates to prepare modulators of PP2A and inhibitors prepared using such methods. Further embodiments relate to biochemical analyses of the interactions of PP2A alone or in complex with Tau. Further embodiments relate to compositions including mimetics and small molecules, optionally, secondary agents, which may be used to treat disorders in which PP2A activity and/or Tau plays a contributing role.