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CYCLOPEPTIDES CONTAINING RGD MIMETICS AS IMAGING MARKERS FOR INTEGRINS
CYCLOPEPTIDES CONTAINING RGD MIMETICS AS IMAGING MARKERS FOR INTEGRINS
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机译:包含RGD类似物的环肽作为整合素的成像标记
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摘要
Radiolabeled cyclic polypeptides, pharmaceutical compositions comprising radiolabeled cyclic polypeptides, and methods of using the radiolabeled cyclic polypeptides. Such polypeptides can be used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT). The radionuclide label is a positron or gamma emitter, e.g. 18F. The polypeptide core is a backbone cyclic RGD derivative of formula: (I) wherein R1 and R8 are side chains of natural or unnatural amino acids and w is an integer from 1 to 5.
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