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TREATMENTS FOR EXCITOTOXICITY AND Aß-MEDIATED TOXICITY AND AGE-ASSOCIATED NEURONAL DYSFUNCTION
TREATMENTS FOR EXCITOTOXICITY AND Aß-MEDIATED TOXICITY AND AGE-ASSOCIATED NEURONAL DYSFUNCTION
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机译:兴奋性毒性和介导的毒性与年龄相关的神经功能障碍的治疗
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摘要
The invention relates to compounds for preventing, inhibiting or antagonising fyn from phosphorylating an amino acid residue in a molecule having an amino acid sequence shown in SEQ ID NO: 1. Typically the compound is capable of binding to fyn, to prevent fyn from migrating to a region of a nerve cell cytosol adjacent a post synaptic membrane and in one embodiment the compound holds or otherwise sequesters fyn within the nerve cell soma. The invention also relates to the treatment or prevention of conditions, diseases or syndromes that are particularly, but not exclusively, a consequence of excitotoxicity or associated with excitotoxicity.
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机译:本发明涉及用于防止,抑制或拮抗fyn使具有SEQ ID NO:1所示氨基酸序列的分子中的氨基酸残基磷酸化的化合物。典型地,该化合物能够与fyn结合,以防止fyn迁移至突触后膜附近的神经细胞胞质溶胶区域,并且在一个实施方案中,该化合物在神经细胞体中保持或以其他方式隔离。本发明还涉及特别是但非排他地,由于兴奋性中毒或与兴奋性中毒有关的病症,疾病或综合症的治疗或预防。
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