ENHANCING ANTIGEN-SPECIFIC CD8+ T CELL RESPONSE USING IRF-7 MRNA

摘要

The invention provides compositions and methods useful for treating a subject in need thereof by stimulating an immune response. In some embodiments, the compositions and methods increase the population size of at least one type of CD8+ T cells in vivo or in vitro, such as transitory effector memory cells. The compositions are antigen-presenting cells that have been transfected with RNA encoding the regulatory factor IRF-7 as well as T cell populations induced by those APCs. In some embodiments, the APCs of the invention further comprise RNA encoding at least one antigen. The compositions of the invention can be administered to a subject to stimulate an immune response.