FATTY ACID BINDING PROTEIN IN THE PATHOGENESIS OF CARDIAC DYSFUNCTION

摘要

The present invention relates to an inhibitor of fatty acid binding protein (FABP) function and/or expression and/or secretion from fat tissue and/or adipocytes and/or binding and/or uptake of FABP protein into cells or tissue for the treatment and/or prevention of diseases selected from the group consisting of cardiac insufficiency, diseases associated with cardiac hypertrophy, diseases associated with a dysfunction of heart contractility, diseases associated with myocardial ischemia secondary to coronary artery spasm, and diseases associated with blood vessel contraction. The invention also relates to methods of identifying compounds suitable as lead compounds or as medicaments for the treatment of these diseases as well as methods of determining a predisposition of an overweight and obese patient for these diseases.