首页>
外国专利>
HUMAN IgM ANTIBODIES TO CHEMOKINE RECEPTORS
HUMAN IgM ANTIBODIES TO CHEMOKINE RECEPTORS
展开▼
机译:人类IgM趋化因子受体抗体
展开▼
页面导航
摘要
著录项
相似文献
摘要
Human sera from normal (i.e., non-HIV infected) individuals contain certain IgM autoantibodies reactive to chemokine and other lymphocyte-surface receptors. A subset of these IgM autoantibodies that bind to such receptors, particularly CXCR4 and CCR5 receptors, can inhibit HIV-1 from infecting cells. Progression from an asymptomatic HIV-1 infected state to AIDS is determined in part by the level of IgM autoantibodies that inhibit HIV-1 from infecting cells. The claimed invention described herein is a method of using these isolated antibodies for the inhibition of the progression of virus-mediated diseases.
展开▼