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SCREENING METHOD FOR IDENTIFYING PROTECTIVE SUBSTANCES FOR TREATING NEURODEGENERATIVE AND/OR ISCHEMIC DISORDERS
SCREENING METHOD FOR IDENTIFYING PROTECTIVE SUBSTANCES FOR TREATING NEURODEGENERATIVE AND/OR ISCHEMIC DISORDERS
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机译:识别用于治疗神经退行性和/或缺血性疾病的保护性物质的筛选方法
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摘要
The present invention relates to a screening method for the identification of protective substances which influence haemoglobin formation in neuronal, myocardial and/or skeletomuscular cells, as well as to recombinant constructs, host cells and transgenic animals for the implementation of this method. In addition, the present invention relates to a diagnostic method for the differential diagnosis of neurodegenerative and/or ischaemic diseases in mammals and the use of haemoglobin, a globin or a mutein or fusion protein thereof or a corresponding nucleic acid for the treatment of neurodegenerative and/or ischaemic diseases in mammals. The invention furthermore relates to constructs for gene therapy of such diseases.
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