FORMULATION BASED ON MICRONIZED CLINOPTILOLITE AS THERAPEUTIC AGENT PROVIDING HIGHLY BIOAVAILABLE SILICON

摘要

This invention relates to a formulation based on micronized clinoptilolite (MC) as therapeutic agent for effective release of highly bioavailable silicon. The formulation comprising variable portions of: (i) micronized clinoptilolite (MC) of general formula: (Men+)x/n[(AlO2)x(SiO2)y]-mH2O (MC) where Me= H, Li, Na, K, Mg, Ca, Zn, Ag, Cu, Mn, Fe; whereas ratio of silicon to aluminum, y:x is between 2.6:1 to 5: 1; number of crystalline water m is from 0 to 20, which is characterized by particles size from 500 nm to 5 μm; and of (ii) one or more excipients which yield in desired pharmaceutical form: tablets, capsules, ointments, creams, gels, lotions, shampoos, powders, liquid powders, compact powders, masks, suppositories, syrups, suspensions, soaps, and therapeutic patches; and of one or more pharmaceutical or cosmetic active substances which contribute and/or enhance basic biological actions of silicic acid. The use of the formulation provides all known positive therapeutic effects of highly bioavailable silicon: stimulation of immune system; treatment of allergic conditions; adjuvant terapy at microbial infections; increasing strength of blood vessels walls, and decreasing of their wall permeability; stimulation of joints and ligaments functions; stimulation of osteoblasts and bone mineralizations; prevention of osteoporosis; decreasing resorption of aluminum from gastrointestinal tract; improving structure of cartilage; antiinflammatory action at various acute or chronic inflammatory diseases; treatment of various skin diseases such as skin irritations, ekzema, seborrheic dermatitis, neurodermitis, atopic dermatitis, psoriasis; treatment of decubitus; treatment of wounds and burns; stimulation of biosynthesis of collagen and elastin; slowing down of skin ageing; reduction of wrinkles; stimulation of hair growth, strength, and brightness; and stimulation of nails growth and strength.