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A FREQUENCY-SHIFT CMOS MAGNETIC BIOSENSOR ARRAY WITH SINGLE BEAD SENSITIVITY AND NO EXTERNAL MAGNET
A FREQUENCY-SHIFT CMOS MAGNETIC BIOSENSOR ARRAY WITH SINGLE BEAD SENSITIVITY AND NO EXTERNAL MAGNET
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机译:频率敏感的CMOS磁性生物传感器阵列,具有单珠敏感度且无外部磁体
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摘要
According to one aspect, an integrated magnetic particle measurement device for detecting a presence or absence of magnetic particles in a sample volume includes at least one sensor cell having a differential sensor pair. An active sensor oscillator frequency is responsive to one or more magnetic particles situated within a sample volume. The sensor cell is configured to be operative in the absence of an externally applied magnetic field. A frequency measurement circuit provides as a time-multiplexed output a first count representative of the active sensor oscillator frequency and a second count representative of the reference sensor oscillator frequency. A calculated difference between the first count and the second count is indicative of a presence or an absence of one or more magnetic particles within the sample volume. An integrated magnetic particle measurement system array and a method for detecting one or more magnetic particles are also described.
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