Disclosed are: a method for predicting the teratogenesis of a chemical substance, which comprises the steps of (1) determining the activity of the chemical substance to inhibit the differentiation of a stem cell derived from a mammal (SD), the an activity of the chemical substance to inhibit the proliferation of a differentiated cell derived from a mammal (DG) and optionally the activity of the chemical substance to inhibit the proliferation of a stem cell derived from a mammal (SG), (2) comparing the inhibitory activity (SG) or the inhibitory activity (DG) with a reference value that is set in advance, and (3) comparing the inhibitory activity (SD) with the inhibitory activity (DG); and others.
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