The present invention aims to provide a substance(s), especially a peptide(s) capable of inhibiting the TGF-² activation reaction. The present invention provides a peptide consisting of 11 to 50 amino acid residues, which comprises an amino acid sequence, Gln-Ile-Leu-Ser-X1-X2-X3-X4-Ala-Ser-Pro wherein each of X1 to X4 independently represents any given amino acid residue, and X1-X2-X3-X4 is a sequence that is not Lys-Leu-Arg-Leu and is not cleavable by proteases.
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