首页>
外国专利>
FATTY ACID BINDING PROTEINS AS DRUG TARGETS FOR MODULATION OF ENDOCANNABINOIDS
FATTY ACID BINDING PROTEINS AS DRUG TARGETS FOR MODULATION OF ENDOCANNABINOIDS
展开▼
机译:脂肪酸结合蛋白作为药物调节内毒素的靶标
展开▼
页面导航
摘要
著录项
相似文献
摘要
The invention provides a method of modulating the level of an endocannabinoid in a subject in need thereof comprising administering an effective amount of an agent that inhibits the interaction of the endocannabinoid with an intracellular fatty acid binding protein (FABP). The invention also provides a method of identifying an agent for modulating the level of an endocannabinoid in a subject comprising testing the agent for its ability to modulate binding of the endocannabinoid with an intracellular FABP. The invention also provides a method of identifying an agent for modulating the level of an endocannabinoid in a subject comprising testing the agent for its ability to modulate expression of an intracellular FABP. The invention also provides a method of identifying an agent for treatment of a neurological disorder comprising testing the agent for its ability to modulate the interaction of an endocannabinoid with an intracellular FABP. The invention also relates to modulation of levels of fatty acid amides for treatment or amelioration of diseases or disorders by modulating binding of the fatty acid amides to fatty acid binding proteins. In one embodiment, the fatty acid binding protein is one or more of FABP3, FABP5, and FABP7. In one embodiment, the level of an endocannabinoid is modulated.
展开▼