DETERMINING A PREDISPOSITION TO CANCER BY IDENTIFICATION OF GENOTYPE COMBINATIONS OF SPECIFIC VARIANTS OF THE GENES CYP1B1, BRCA2 AND CHEK2

摘要

The present invention is providing the methods, uses and compositions useful in diagnosis of predisposition to human cancers of various sites wherein genotype combinations of constitutional variants of alterations within CYP1B1, CHEK2 and BRCA2 gene are analyzed in biological material from examined individual, wherein the increase in cancer risk is qualitatively and quantitatively different than the sum of the low-risk effects of the mentioned variants of these three genes when taken separately. The mode can be applied for examination of all persons of Polish origin and most probably also from other ethnic groups.