BIOSENSOR DEVICE AND SENSING METHOD ALLOWING REAL-TIME DETECTION OF PHYSICAL CHANGES IN BIOLOGICAL MATERIALS

摘要

The present invention relates to a biosensor device and sensing method allowing real-time detection while biological materials are reacting and transforming, such that biological materials can be accurately observed. The present invention provides a structure and method which not only allow detection of the presence or absence and the extent of reaction of biological materials by means of an SPR sensor using the phenomenon of Surface Plasmon Resonance but also allow real-time detection of physical changes in biological materials as the changes actually occur, from the time when a biological material reaction takes place until the time when it is completed, by probing the surface of the biological material by means of an Atomic Force Microscope (AFM) for real-time observations.