首页> 外国专利> A NOVEL IN VITRO HIV-1 LATENCY MODEL FOR SCREENING REACTIVATION AGENTS OF HIV-1

A NOVEL IN VITRO HIV-1 LATENCY MODEL FOR SCREENING REACTIVATION AGENTS OF HIV-1

机译:新型的HIV-1潜伏期模型,用于筛选HIV-1的活化因子。

摘要

In one aspect, the present invention provides an isolated Bcl-2-transduced cell that comprises, integrated into the genome of the cell, a transcription-competent immunodeficiency virus or a transcription-competent immunodeficiency virus-based retroviral vector. Under basal in vitro culture conditions, the immunodeficiency virus is latent, and the expression of the latent immunodeficiency virus can be reactivated. The present invention further provides screening methods for identifying agents capable of reactivating latent immunodeficiency virus or blocking the reactivation of latent immunodeficiency virus. In another aspect, the present invention provides such identified agents and methods for treating subject having an immunodeficiency virus infection.
机译:一方面,本发明提供了分离的Bcl-2转导的细胞,其包含整合到细胞基因组中的,具有转录能力的免疫缺陷病毒或基于转录能力的免疫缺陷病毒的逆转录病毒载体。在基础体外培养条件下,免疫缺陷病毒是潜在的,并且可以重新激活潜在免疫缺陷病毒的表达。本发明进一步提供了筛选方法,用于鉴定能够再活化潜伏免疫缺陷病毒或阻断再潜伏免疫缺陷病毒的试剂。在另一方面,本发明提供了用于治疗患有免疫缺陷病毒感染的受试者的此类鉴定的试剂和方法。

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