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PROCESS FOR THE PREPARATION OF SODIUM SALT OF L-(((L(R)-(3-(2-(7-CHLORO-2- QUINOLINYL)-ETHENYL)PHENYL)-3-(2-(L-HYDROXY-L- METHYLETHYL)PHENYL)PROPYL)SULFANYL)METHYL)CYCLOPROPANEACETIC ACID
PROCESS FOR THE PREPARATION OF SODIUM SALT OF L-(((L(R)-(3-(2-(7-CHLORO-2- QUINOLINYL)-ETHENYL)PHENYL)-3-(2-(L-HYDROXY-L- METHYLETHYL)PHENYL)PROPYL)SULFANYL)METHYL)CYCLOPROPANEACETIC ACID
The invention relates to a novel process for the preparation of Sodium salt of 1- (((l(R)-(3-(2-(7-chloro-2-quinolinyl)-ethenyl)phenyl)-3-(2-(l-hydroxy-l- methylethyl)phenyl) propyl)sulfanyl)methyl)cyclopropaneacetic acid wherein the crystalline forms of methanesulfonate and Montelukast are not isolated. Furthermore, the invention relates to a novel process for preparing salt of 1-(((1(R)- (3-(2-(7-chloro-2-quinolinyl)-ethenyl)phenyl)-3-(2-(l-hydroxy-l- methylethyl)phenyl)propyl)sulfanyl)methyl)cyclopropaneacetic acid with tert- butylamine and the method for its purification to achieve pharmaceutical purity.
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